Sambria Pharmaceuticals Drug Delivery System

The Sambria Pharmaceuticals Drug Delivery System was created to allow therapeutic molecules to enter the skin rapidly while also limiting the systemic entry of those molecules. The reason why the Sambria Pharmaceuticals Drug Delivery System was originally conceptualized was to improve therapeutic outcomes of local therapies while improving the safety of using these same medications. Some examples of the molecules where safety may be improved are anesthetics such as lidocaine, non-steroidal anti-inflammatory drugs, such as acetaminophen (also known by brand name as Tylenol) and others where there is a benefit to local topical application and a limit of systemic entry.

 

Among other possible medicines where this benefit can improve outcomes and limit health risks, both lidocaine and acetaminophen can cause harm if too much enters the blood stream. When too much lidocaine enters the blood stream there is a risk that it can dangerously lower blood pressure and heart rate as well as depress the respiratory system (reduce the body’s ability to fill the lungs with air). There is also a known risk from the use of acetaminophen to the liver, cardiovascular system and hearing when too much enters and builds up or stays in the blood stream. By applying the Sambria Pharmaceuticals Drug Delivery System to these medications, one study showed that there is an improved effect as well as a limiting factor on the intact active pharmaceutical ingredient (known as API) entering the circulatory system. There will continue to be ongoing studies to demonstrate these effects from using the Sambria Pharmaceuticals Drug Delivery System.

 

What is the Sambria Pharmaceuticals Drug Delivery System?

 

The Sambria Pharmaceuticals Drug Delivery System is a chemical combination supplied in a cream form used to rapidly and effectively deliver drugs into a localized area in the skin that is designed to limit systemic entry as described above. It takes into account several factors related to how skin protects the inside of the body to shield it from environmental contaminants. The top layer of the skin is called the stratum corneum. This layer is a combination or proteins, known as keratinoid structures and fatty acids known as a bilipid layer. In combination these structures create a protective barrier. This protective barrier can be temporarily altered to allow small therapeutic molecules to be absorbed into the skin.

 

The Sambria Pharmaceuticals Drug Delivery System is included in all of the current line of NeuroMed Brand Topical Anesthetic Products.

 

Sambria Pharmaceuticals Drug Delivery System

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